Matthew A. Wallig
Professor, Pathobiology
Chair of Comparative Pathology, Pathobiology
Professional Interests: Dr. Wallig's professional interests include studying the potential synergy that exists between bioactive compounds found in cruciferous vegetables (e.g. broccoli, Brussels sprouts, cabbage) and the prevention of cancer. Dr. Wallig also has numerous collaborative projects related to the chemopreventive effects of phytochemicals with faculty in several other departments including Nutritional Sciences, Food Science & Human Nutrition and Natural Resources & Environmental Sciences. Among those projects are the effects on grapeseed extract on the prevention of colon cancer, green teas and their prevention of liver cancer, and glucosinolate derivatives from broccoli and their effects on prevention of a variety of cancers. In addition, he collaborates on projects defining the effects of fructose on lipid metabolism, dietary fiber and infant formulas and their impacts on neonatal gut development and the influence of exercise on tumor growth and development. Dr. Wallig is also Residency Coordinator for Anatomic Pathology and Advisor for the Student Chapter of the ACVP. His major focus is teaching pathology at the professional and graduate levels.
Image: GST-P positive focus AFB1-treated rat 40x
Selected Publications:
Adhikari, S., Ang, A.D., Clement, M.V., Wallig, M.A., Bhatia, M. Crambene induces pancreatic acinar cell apoptosis via the activation of mitochondrial pathway. American Journal of Physiology [Gastrointestinal and Liver Physiology] 291:95-101, 2006.
Jung K-J, Wallig MA, Singletary KW. Purple grape juice inhibits 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation. Cancer Letters 233:279-288, 2006.
Apanavicius, C.J., Powell, K.L., Vester, B.M., Karr-Lilienthat, L.K., Pope, L.L., Fastinger, N.D., Wallig, M.A., Tappenden, K.A., and Swanson, K.S. Fructan supplementation attenuates decreased food intake and epithelial cell sloughing from Salmonella challenge in weanling pigs. Journal of Nutrition 137(8):1923-1930, 2007.
Heller, D.A., Fan, T.M., de Lorimier, L.P., Charney, S.C., Barger, A., Tannehil-Gregg, S.H., Rosol, T.J., and Wallig, M.A., COX-2 in Cancer: A critical comparison of protein expressions and in vitro enzymatic activity. Journal of Veterinary Internal Medicine 21(5):1048-1055, 2007.
Cao, Y., Adhikar, S., Clement, V., Wallig, M., Bhatia, M. Inductions of apoptosis by crambene protect mice against acute pancreatitis via anti-inflammatory pathways. American Journal of Pathology 170(5):1521-1533, 2007.
Lai, R-H., Keck, A.S., Wallig, M.A., West, L.G., Jeffery, EH. Similarity of bioactivity between purified and semipurified glucoraphanin. Food and Chemical Toxicology 46(1): 195-202, 2008.
Newman, R.G., Kitchell, B.E., Wallig, M.A., Paria, B.C. The cloning and expression of matrix metalloprroteinase-2 and tissue inhibitory of matrix metalloproteinase 2 in normal canine lymph nodes and in canine lymphoma. Research in Veterinary Science 84(2):206-214, 2008.
Keylock, K.T., Viera, V.J., Wallig, M.A., DiPietro, L.A., Schrementi, M., Woods, J.A. Exercise accelerates cutaneous wound healing and decreases wound inflammation in aged mice. American Journal of Physiology [Regulatory, Integrative & Comparative Physiology] 294(1):R179-84, 2008.
Koo, H-Y, Wallig, M.A., Chung, B.H., Nara, T.Y., Cho, B.H.S., Nakamura, M.T. Dietary fructose induces a wide range of genes with distinct shift in carbohydrate and lipid metabolism in fed and fasted rat liver. Biochimica et Biophysica Acta – Molecular Basis of Disease, in press.
