Philip F. Solter
Associate Professor, Pathobiology
Professional Interests: Veterinary
clinical biochemistry.
The diagnosis of disease frequently begins with blood tests. My research interests are in understanding the pathophysiological mechanisms that cause blood test results to change, and to develop new tests for use in nonhuman animal species.
Past studies in my laboratory have included those examining the pathophysiological mechanisms by which increased serum alkaline phosphatase activity occurs, and the mechanisms of hepatic toxicity of the protein phosphatase inhibitor, microcystin-LR. My current focus is in evaluating diagnostic tests of heart failure for use in veterinary species. Currently, there are few such tests available. My laboratory is also determining the changes that occur to cardiac protein expression in canine dilated cardiomyopathy in order to gain some idea as to the underlying disease mechanisms responsible for myocardial failure.
Selected Publications:
Oyama MA, Sisson DD, Solter PF. Prospective screening for occult cardiomyopathy in dogs by measurement of plasma atrial natriuretic peptide, B-type natriuretic peptide, and cardiac troponin-I concentrations. American Journal of Veterinary Research 68:42-47, 2007.
Prosek R, Sisson D, Oyama M, Solter P. Distinguishing cardiac and non-cardiac dyspnea in 48 dogs via plasma atrial natriuretic factor, B-type natriuretic factor, endothelin and cardiac troponin-I. Journal of Veterinary Internal Medicine 21:238-242, 2007.
Santos AP, Biondo AW, Sisson DD, Lopes STA, Sousa C, Solter PF. Comparative sequences of the canine and feline vasopressin prohormones. Comparative Clinical Pathology 16:173-179, 2007.
Solter PF, Oyama MA, Sisson DD. Canine Heterophilic Antibodies Documented as a Source of False Positive ELISA Results. In Press, Veterinary Clinical Pathology.
Lopes R, Solter PF, Sisson DD, Oyama MA and Prosek R. Correlation of mitochondrial protein expression in complexes I to V with natural and induced forms of canine idiopathic dilated cardiomyopathy. American Journal of Veterinary Research 67:971-977, 2006.
Lopes R, Solter PF, Sisson DD, Oyama MA and Prosek R. Characterization of canine mitochondrial protein expression in natural and induced forms of Idiopathic Dilated Cardiomyopathy. American Journal of Veterinary Research 67:963-970, 2006.
Solter PF. Clinical pathology approaches to hepatic injury. Toxicologic Pathology 33:1-8, 2005.
Prosek R, Sisson DD, Oyama MA, Biondo AW and Solter PF. Endothelin-1 in Dogs with Acquired Heart Disease with and without Congestive Heart Failure. Journalof Veterinary Internal Medicine 18:840-844, 2004.
Prosek R, Sisson D, Oyama M, Biondo A and Solter P. Measurements of plasma endothelin immunoreactivity in healthy cats and cats with myocardial disease. Journal of Veterinary Internal Medicine 18:826-830, 2004.
Biondo AW, Wiedmeyer CE, Sisson DD and Solter PF. Comparative sequences of canine and feline endothelin-1. Veterinary Clinical Pathology 32:188-194, 2003.
Guzman R and Solter P, Runnegar M. Inhibition of nuclear phosphatase activity in mouse hepatocytes by the cyanobacterial toxin microcystin-LR. Toxicon 41:773-781, 2003 .
Guzman RE, Solter PF. Characterization of sublethal microcystin-LR exposure in mice. Veterinary Pathology 39:17-26, 2002.
Solter P, Sisson D, Thomas W and Goetze L. Intrarenal effects of ecadotril during acute volume expansion in dogs with congestive heart failure. Journal of Pharmacology and Experimental Therapeutics 293:989-995, 2000.
Solter PF, Hoffmann WE, Chambers MD and Schaeffer DJ. CCK-8 infusion increases plasma LMW alkaline phosphatase coincident with enterohepatic circulation of bile acids. American Journal of Physiology 273 (Gastrointestinal and Liver Physiology 36) G381-G388, 1997.
Solter PF and Hoffmann WE. Canine corticosteroid-induced alkaline phosphatase isoenzyme in serum was solubilized by phospholipase activity in vivo. American Journal of Physiology 269 (Gastrointestinal and Liver Physiology 32) G278-G286, 1995.
