James F. Zachary
Professor, Experimental Pathology
Professional Interests: Models for human disease
Selected Publications:
Teuscher, C.; Milligan, G.; Zachary, J. F.; Blankenhorn, E. P.: Histamine H1 receptor is required for TCR mediated p38 MAP kinase activation and IFN-Gamma production. J Clin Invest, in press, 2007.
Teuscher, C.; Subramanian, M.; Noubade, R.; Gao, J. F.; Offner, H.; Zachary, J. F.; Lovenberg, T. W.; Liu, C.; Blankenhorn, E. P.: Central histamine H3 receptor signaling negatively regulates autoimmune inflammation of the brain. P Natl Acad Sci USA, 104:10146-51, 2007.
Jacobson, A. C.; Ma, Y.; Zachary, J. F.; Weis, J. H.; Weis, J. J.: Mice lacking CD21/35 proteins mount effective immune responses against B.burgdorferi infection. Infect Immun, 75:2075-2078, 2007.
Crandall, H.; Dunn, D.; Ma, Y.; Wooten, R. M.; Zachary, J. F.; Weis, J. H.; Weiss, R. B.; Weis, J. J.: Gene expression profiling reveals unique pathways associated with differential severity of lyme arthritis. J Immunol, 177:7930-7942, 2006.
Zachary, J. F.; Blue, J. P.; Miller, R. J.; Ricconi, B. J.; Eden, G.; O'Brien Jr., W. D.: Lesions of ultrasound-induced lung hemorrhage are not consistent with thermal injury. Ultrasound Med Bio, 32:17631770, 2006.
Zachary, J. F.; Blue, J. P.; Miller, R. J.; O'Brien Jr., W. D.: Vascular lesions and s-thrombomodulin concentrations from auricular arteries of rabbits infused with microbubble contrast agent and exposed to pulsed ultrasound. Ultrasound Med Bio, 32:17811791, 2006.
Teuscher, C.; Noubade, R.; McElvany, B.; Bunn, J. Y.; Fillmore, P. D.; Zachary, J. F.; Blankenhorn, E. P.: Evidence that the Y-chromosome influences autoimmune disease in male and female mice. P Natl Acad Sci USA, 103:8024-8029, 2006.
Crandall, H.; Ma, Y.; Dunn, D.; Sundsbak, R.; Holmdahl, R.; Oloffson, P.; Zachary, J. F.; Weis, J. H.; Weiss, R.; Teuscher, C.; Weis, J. J.: Bb2Bb3 regulation of murine Lyme arthritis is distinct from Ncf1 and independent of the phagocyte nicotinamide adenine dinucleotide phosphate oxidase. Am J Pathol, 167:775-785, 2005.
Wang, X.; Ma, Y.; Weis, J. H.; Zachary, J. F.; Kirschning, C. J.; Weis, J. J.: Relative contributions of innate and acquired host responses to bacterial control and arthritis development in lyme disease. Infect Immun, 73:657-660, 2005.
Teuscher, C.; Bunn, J. Y.; Fillmore, P. D.; Butterfield, R. J.; Zachary, J. F.; Blankenhorn, E. P.: Gender, age, and season at immunization uniquely influence the genetic control of susceptibility to histopathological lesions and clinical signs of experimental allergic encephalomyelitis: implications for the genetics of multiple sclerosis. Am J Pathol, 165:1593-602, 2004.
Bolz, D. D.; Sundsbak, R. S.; Ma, Y.; Akira, S.; Kirschning, C. J.; Zachary, J. F.; Weis, J. H.; Weis, J. J.: MyD88 plays a unique role in host defense but not arthritis development in lyme disease. J Immunol, 173:2003-2010, 2004.
Polanczyk, M.; Zamora, A.; Subramanian, S.; Tovey, M.; Vandenbark, A. A.; Offner, H.; Yellayi, S.; Zachary, J. F.; Fillmore, P. D.; Blankenhorn, E. P.; Gustafsson, J. A.; Teuscher, C.: Estrogen receptor-1 (Esr1) and -2 (Esr2) regulate the severity of clinical experimental allergic encephalomyelitis in male mice. Am J Pathol, 164:1915-1924, 2004.
Teuscher, C.; Offner, H.; Zamora, A.; Poynter, M. E.; Watanabe, T.; Zachary, J. F.; Blankenhorn, E. P.: Attenuation of Th1 effector cell responses and susceptibility to experimental allergic encephalomyelitis in histamine H2 receptor knockout mice is due to dysregulation of cytokine production by antigen presenting cells. Am J Pathol, 164:883-892, 2004
Fillmore, P.; Blankenhorn, E. P.; Zachary, J. F.; Teuscher, C.: Adult gonadal hormones selectively regulate sexually dimorphic quantitative traits observed in experimental allergic encephalomyelitis. Am J Pathol,164:167-175, 2004.
Lawrenz, M. B.; Wooten, R. M.; Zachary, J. F.; Drouin, S. A.; Weis, J. J.; Wetsel, R. A.; Norris, S. J.: Effect of complement component C3 deficiency on experimental Lyme borreliosis in mice. Infect Immun, 71:4432-4440, 2003.
Ma, R. Z.; Gao, J,; Meeker, N. D,; Fillmore, P. D.; Tung, K. S. K.; Watanabe, T.; Zachary, J. F.; Offner, H.; Blankenhorn, E. P.; Teuscher, C.: Identification of Bphs, an autoimmune disease locus, as histamine receptor H1. Science, 297:620-623, 2002.
