Duncan C. Ferguson
Department Head, Veterinary Biosciences
Professional Interests: Thyroid
hormone physiology, pharmacology and toxicology; mechanisms of action
of environmental thyroid hormone disrupting compounds on neurodevelopment;
etiopathogenesis of hyperthyroidism in the cat; use of molecular genetic
techniques for improvement of thyroid diagnostic tests in domestic animals;
mechanisms of obesity, insulin resistance, and Type II diabetes mellitus
in the cat model; veterinary clinical pharmacology.
Selected Publications:
Hoenig M, Thomaseth K, Waldron M and Ferguson DC. Fatty acid turnover, substrate oxidation, and heat production in lean and obese cats during the euglycemic hyperinsulinemic clamp. Domestic Animal Endocrinology, in press, 2006. (available online May 2, 2006)
Hoenig M, Thomaseth K, Waldron M, Brandao J, and Ferguson DC. Assessment and mathematical modeling and insulin sensitivity in lean and obese cats. Domestic Animal Endocrinology, in press, 2006. (available online January 11, 2006)
Fisher JW, Campbell J, Muralidhara S, Bruckner JV, Ferguson DC, Mumtaz M, H El-Masri H, Harmon B, Hedge J, Crofton K and Almekinder TL. Effect of PCB 126 on hepatic metabolism of thyroxine and pertubations in the hypothalamic- pituitary-thyroid axis in the rat. Toxicological Sciences 90(1): 87-95, 2006.
Rayalam S, Eizenstat LD, Davis RR, Hoenig M and Ferguson DC. Expression and purification of feline thyrotropin (fTSH): immunological detection and bioactivity of heterodimeric and yoked glycoproteins. Domestic Animal Endocrinology 30:185-202, 2006.
Rayalam S, Eizenstat LD, Hoenig M, and Ferguson DC. Cloning and sequencing of feline thyrotropin (fTSH): heterodimeric and yoked constructs, Domestic Animal Endocrinology 30:203-217, 2006.
Hoenig M, Caffall ZF, McGraw RA, and Ferguson DC. Cloning, expression and purification of feline proinsulin. Domestic Animal Endocrinology 30:28-37, 2006.
Schachter S, Nelson RW, Scott-Moncrieff C, Ferguson DC, Feldman EC, Montgomery T and Neal L. Comparison of serum free thyroxine concentration determined by standard equilibrium dialysis, modified equilibrium dialysis, and five radio immunoassays in dogs. J Vet Int Med 18:259-264, 2004.
Brennan CL, Ferguson DC and Hoenig M. GLUT4 but not GLUT 1 expression decreases early in the development of feline obesity. Dom Anim Endocrinol 26:291-301, 2004.
Wilkins C, Long R, Waldron M, Ferguson DC, and Hoenig M. Assessment of the influence of fatty acids on indices of insulin sensitivity and myocellular lipid content by use of magnetic resonance spectroscopy in cats. Am J Vet Res 65(8):1090-9 2004.
Hoenig M and Ferguson DC. Effect of darglitazone on glucose clearance and lipid metabolism in obese cats. Am J Vet Res 64:1409-1413, 2003.
Hoenig M, Wilkins C, Holson J and Ferguson DC. Effects of obesity on lipid profiles in lean and obese cats. Am J Vet Res 64:299-303, 2003.
Hoenig M, Alexander S, Holson J and Ferguson DC. Influence of glucose dosage on interpretation of intravenous glucose tolerance tests in lean and obese cats. J Vet Int Med 16(5):529-532, 2002.
Hoeni M and Ferguson DC. Effects of neutering on hormonal concentrations and energy requirements in male and female cats. Am J Vet Res 63(5):634-9, 2002.
Hoenig M, Laflamme D, Klaser DA, Singer MJ and Ferguson DC. Glucose tolerance and lipid profiles in dogs fed different fiber diets. Vet Therapeutics 2: 160-169, 2001.
Yang X, McGraw RA and Ferguson DC. cDNA cloning of canine common a gene and its Co-expression with canine thyrotropin b gene in baculovirus expression system. Domestic Animal Endocrinology 18(4): 379-393, 2000.
Yang X, McGraw RA, Su X Su, Katakam P, Grosse WM, Li OW and Ferguson DC. Canine Thyrotropin b -Subunit Gene: Cloning and expression in Escherichia coli , generation of monoclonal antibodies, and transient expression in the Chinese Hamster Ovary cells. Domestic Animal Endocrinol 18(4): 363-378, 2000.
Michels GM, Boudinot FD, Ferguson DC, and Hoenig M. Pharmacokinetics of the insulin-sensitizing agent, troglitazone, in cats. Am J Vet Res 61(7): 775-778, 2000.
Hoenig M, Hall G, Ferguson D, Jordan K, Henson M, Johnson K and O'Brien T. A feline model of experimentally induced islet amyloidosis. Am J Pathology 157(6): 2143 � 2150, 2000.
Hoenig M, McGoldrick JB, deBeer M, Demacker PNM and Ferguson DC. Activity and tissue-specific expression of lipases and tumor-necrosis factor a in lean and obese cats. Domestic Animal Endocrinology 30: 333-344, 2006.
