Paul S. Cooke
Professor and Billie Alexander Field Chair in Reproductive Biology,
Veterinary Biosciences
Chair of Morphology Division, Veterinary Biosciences
Professor and Billie Alexander Field Chair in Reproductive Biology, Veterinary Biosciences
Chair of Morphology Division, Veterinary Biosciences
Professional Interests: Reproductive biology, obesity and developmental toxicology. Current research: Regulation of stem cell spermatogonia by Sertoli cells; role of steroid hormones and thyroid hormone in development of male and female reproductive organs; role of estrogens in the establishment of adipocyte number and obesity.
Selected Publications:
Heine PA, Taylor JA, Iwamoto GA, Lubahn DB, Cooke PS. (2000) Increased adipose tissue in male and female estrogen receptor-alpha knockout mice. Proc Natl Acad Sci U S A. 97:12729-34.
Yellayi S, Naaz A, Szewczykowski MA, Sato T, Woods JA, Chang J, Segre M, Allred CD, Helferich WG, Cooke PS. (2002) The phytoestrogen genistein induces thymic and immune changes: a human health concern? Proc Natl Acad Sci U S A. 99:7616-21.
Cooke PS, Hess RA, Simon L, Schlesser HN, Carnes K, Tyagi G, Hofmann M-C, Murphy KM. (2006) The transcription factor Ets-Related Molecule (ERM) is essential for stem cell maintenance and self-renewal. Animal Reproduction 3:98-107.
Sridharan S, Simon L, Meling DD, Cyr DG, Gutstein DE, Fishman GI, Guillou F, Cooke PS. (2007) Proliferation of adult Sertoli cells following conditional knock out of the gap junctional protein GJA1 (Connexin 43) Biology of Reproduction 76:804-812.
Cooke PS, Holsberger D, Cimafranca M, Meling D, Beals C, Nakayama K, Nakayama K, Kiyokawa H. (2007) The F box protein Skp2 regulates adipose mass and adipocyte number in vivo. Obesity 15:1400-1408.
Simon L, Ekman GC, Tyagi G, Hess RA, Murphy KM, Cooke PS. (2007) Common and distinct factors regulate expression of ERM and GDNF, Sertoli cell proteins essential for spermatogonial stem cell maintenance. Experimental Cell Research 313:3090-3099.
