Matthew C. Stewart
Assistant Professor, Veterinary Clinical Medicine
Director, Research and Graduate Studies, Veterinar Clinical Medicine
Professional Interests: Pathophysiology
of musculoskeletal disease in the horse and chrondrocyte biology; the
control of proliferation in articular chondrocytes and the relationship
between cell cycle control and expression of chondrocytic phenotypes
during hypertrophic differentiation.
Selected Publications:
Ballock RT, Ulatowski LM, Chen DHC, Pecorak SC , Economides AN and Stewart MC. Thyroid hormone regulates terminal differentiation of growth plate chondrocytes through local induction of bone morphogenetic protein activity. Submitted to Endocrinology, Nov 2005.
Stewart AA, Goodrich L, Byron C and Stewart MC. The use of intrasynovial catheters to treat synovial infections in 30 horses (July 1996 to July 2003), submitted to American Journal of Veterinary Research, June 2005.
Stewart MC, Fosang AJ, Bai Y , Osborn B , Plaas A and Sandy JD. ADAMTS5-mediated aggrecanolysis in murine epiphyseal chondrocyte cultures. Osteoarthritis and Cartilage, accepted for publication Nov 2005.
Tantro JM, Taki N, Islam AS, Goldberg VM, Rimnac CM, Doerschuk CM, Stewart MC and Greenfield EM The balance between endoto xin accumulation and clearance during particle-induced osteolysis in murine calvaria. Accepted for publication by Journal of Orthopaedic Research, Dec, 2005.
Marcelino J, Rhee DK, Brown M, Gong Y, Smits P, Lefebvre V, Jay GD, Stewart MC, Wang H, Matthew L. Warman ML and Carpten JD. (2005) The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth. Journal of Clinical Investigations 115:622-631.
Byron C, Benson B, Stewart A, Stewart MC, Pondonis H. (2005) Effects of radial pressure waves on equine cartilage explant structure, chondrocyte membrane permeability and chondrocyte viability. American Journal of Veterinary Science 66:1757-1763.
Johnstone B, Stewart M and Yoo J. (2004) Cell sources for cartilage tissue engineering. In: Culture of Cells for Tissue Engineering, eds. Freshney I, Vunjak-Novakovic G, Wiley, NY(in press).
Stewart MC, Kadlcek RM, Robbins P, MacLeod JN, Ballock RT. (2004) Expression and activity of the CDK inhibitor p57 Kip2 in chondrocytes undergoing hypertrophic differentiation. Journal of Bone and Mineral Research 19:123-132.
Welter JF, Solchaga LA and Stewart MC. (2004) High-efficiency nonviral transfection of primary chondrocytes. Methods in Molecular Medicine 100:129-146.
