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Meagan Mann Graduate Research Assistant, Dept. of Chemistry Postdoctoral Fellow, Dept. of Veterinary Biosciences mkmann@uiuc.edu Web: http://kgroup.scs.uiuc.edu/mann.htm |
SHORT BIO: I started college in 1998 at Northern Kentucky University where I worked under Bob Kempton purifying and characterizing synthetic small molecules that could cleave DNA. I graduated in 2003 with BS degrees in biology and chemistry. I started research at UIUC in May 2003 working under Steve Sligar and Chad Rienstra on integration of fluorotryptophan into bacterial proteins for use in solid state 19F-NMR experiments (MAS-NMR) as well as 15N/ 2H labeling. I joined John Katzenellenbogen’s research group in November 2003 to work on my doctoral research. I have worked on site-directed mutagenesis of estrogen receptor α, synthesis of phytoestrogen analogs as selective estrogen receptor ligands, and have developed and synthesized estrogen receptor proteolysis targeting chimeric molecules, or ER PROTACs. I am a chemist by training (chemical biology), but I am also interested in toxicology, molecular biology, biochemistry, environmental science, and genetics as well as how these disciplines merge with traditional chemical research. Benzo-a-pyrene is a component of cigarette smoke and also a member of the polycyclic aromatic hydrocarbon family, similar to dioxin. The second portion of my research is to examine if Benzo-a-pyrene treatment compromises the ability of stromal cells to decidualize and respond to PTHrP. Infertility is most often associated with a failure of implantation due to abnormal alterations in the endometrium. Our goal is to assess if, and how, PTHrP is altered in individuals suffering from infertility and if Benzo-a-pyrene plays a role in disrupting decidualization.
EDUCATION
University of Illinois at Urbana-Champaign (UIUC) Working Thesis Title: “Design and Synthesis of High-affinity Estrogen Receptor Proteolysis Targeting Chimeric Molecules” BS Biology 2003 BS Chemistry (ACS Certified)
POSTER PRESENTATIONS Mann, M; Katzenellenbogen, J. Synthesis of a selective proteolysis inducer (PROTAC): Chemically knocking out Estrogen Receptor function. Presented at the 233rd ACS National Meeting, Chicago, IL, March 2007. Mann, M; Katzenellenbogen, J. Progress on Synthesis of Estrogen Receptor PROTACs. Presented at the Allerton Conference, UIUC, November 2006. Mann, M.; Katzenellenbogen, J. Posttranslational Control of the Estrogen Receptor. Presented at the Toxicology Open House, UIUC, September 2006. Mann, M.; Katzenellenbogen, J. Synthesis of Estrogen Receptor PROTACs. Presented at the Frontiers of Pharmacology and Toxicology International Conference, Chicago, IL, August 2006. HONORS & AWARDS UIUC NIH Toxicology Training Grant 2005-2007 NKU Greaves scholarship in chemistry 2001-2003 Dean’s list/Scholar’s list 8 semesters |
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